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简述苯二氮卓类药物的构效关系。

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第1题
苯二氮䓬类药物的作用机制?解释其构效关系

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第2题
关于苯并二氮?构效关系描述正确的是()

A.7-位引入吸电子基团,活性增强

B.1,4-苯并二氮作环为活性必需结构

C.C5位苯环专属性很高

D.1,2位用杂环稠合,可提高该类药物的代谢稳定性

E.4,5位双键被饱和并并合四氢恶唑环,镇静作用增强

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第3题
二苯并氮卓类抗癫痫药为()

A.盐酸氯胺酮

B.盐酸氯丙嗪

C.盐酸阿米替林

D.盐酸布比卡因

E.卡马西平

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第4题
关于Hl受体拮抗剂构效关系的叙述,正确的是()。

A.光学异构体均显示相同的抗组胺活性

B. 结构中两个芳环处于一个平面时具有最大的抗组胺活性

C. 芳环与叔氮原子距离为0.5~0.6 nm

D. 几何异构体均显示相同的抗组胺活性

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第5题
苯二氮革类的中枢作用主要与增强_________神经的功能有关。

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第6题
苯二氮革类用于A.躁狂症 B.抑郁症 C.焦虑症 D.精神分裂症 E.帕金森征

苯二氮革类用于

A.躁狂症

B.抑郁症

C.焦虑症

D.精神分裂症

E.帕金森征

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第7题
根据材料回答{TSE}题: Alcoholism 1 Yes,alcoholism can be treated.Alcoholism treatment prog
rams use both counseling and medication(药物治疗)to help a person stop drinking.Most alcoholics need help to recover from their disease.With support and treatment,many people are able to stop drinking and rebuild their lives. 2 A range of medication is used to treat alcoholism.Benzodiazepines(苯二氮平类药物)are sometimes used during the first days after a person stops drinking to help him or her safely withdraw from aleohol.However,these medications are not used beyond the first few days because they may be highly addictive.Other medications help people remain sober(清醒).One medication used for this purpose is nahrexone(环丙甲羟二羟吗啡酮).When combined with counseling,naltrexone can reduce the strong desire for alcohol and help prevent a person from returning to heavy drinking.Another medication,disulfiram(戒酒硫),discourages drinking by making the person feel sick if he or she drinks alcohol.Though several medications help treat alcoholism,there is no“magic bullet.”Developing new and more effective medications to treat alcoholism remains a high priority for researchers. 3 Alcoholism treatment works for many people.But just like any chronic disease,there are different levels of SUCCESS in treatment.Some people stop drinking and remain sober.Others cannot stop drinking for any length of time.With treatment,one thing is clear,however,the longer a person stops drinking alcohol,the more likely he or she will be able to stay sober. 4 N0,alcoholism cannot be cured at this time.Even if an alcoholic hasn’t been drinking for a long time,he or she can still return to the drinking habit.To guard against it,an alcoholic must continue to avoid all alcoholic drinks. {TS}Paragraph 1______________

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第8题
写出Maxwell方程组的微分形式,并简述每一个方程的物理意义。再写出场量之间必须满足的媒质本构关
系。

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第9题
简述商品的二因素及其关系。

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第10题
下列不属于苯二氮草类的药物是()

A.氯氮草

B. 奥沙西洋

C. 眠而通

D. 劳拉西泮

E. 艾司唑仑

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